Psychedelics and the Human Receptorome

February 5th, 2010 by fernando

We currently understand the mental effects of psychedelics to be caused by agonism or partial agonism of 5-HT2A (and possibly 5-HT2C) receptors (serotonin-2A and serotonin-2C receptors). This understanding was first developed in the 1980s and has since been confirmed by a large body of evidence, as reviewed recently by Nichols. However, many authors have commented that other receptors may also play a role. In this post-genome era of high-throughput assays, it is time to take a broader view, move beyond the common-denominator approach, and begin to explore the role of other receptors in shaping the mental effects of psychedelics, especially the qualitative differences among them.

The objective of this paper is to present the receptor binding profiles of the thirty-five drugs (Fig. 1  Fig. 2  ) of this study in such a way that they can be easily compared in both their similarities and their differences. This is intended to serve as a reference work on the multi-receptor affinity pharmacology of psychedelic drugs. The tables and figures are the heart of this manuscript. Some of them have been included as “supporting information,” because they exceed the size limits of standard tables and figures. However, this supporting information is no less central to the manuscript than the standard tables and figures.

Continue reading…  

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Trailer: ‘The Secret Life Of…’

February 2nd, 2010 by fernando
I recently returned from Mexico, where I was with a small crew, shooting the pilot episode of a documentary series entitled “The Secret Life Of…” The show is hosted by Dan Glass, and each episode focuses on the lesser known stories behind different psychoactives in cities around the world. For the pilot, we went to Huautla de Jimenez, Mexico, to talk to local Mazatec people about the use of psilocybin mushrooms in healing ceremonies in the area.
Our episode features interviews with anthropologist and author of “The Devil’s Book of Culture,” Ben Feinberg, local curandera Ines Cortes Rodriguez, Mazatec ritual specialist Edward Abse, and a wide variety of local historians, musicians, and business owners.
Watch the trailer:

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Chronic High Doses of Cannabinoids Promote Hippocampal Neurogenesis

January 30th, 2010 by fernando

“The recent discovery that the hippocampus is able to generate new neurons throughout a human’s lifespan has changed the way we think about the mechanisms of psychiatric disorders and drug addiction,” says Wen Jian and colleagues in a study 1 published in the Journal      of Clinical Investigation in 2005. It appears that cannabinoids are able to modulate pain, nausea, vomiting, epilepsy, ischemic stroke, cerebral trauma, multiple sclerosis, tumors, and many other disorders. Cannabinoids act on two types of receptors, the CB1 receptors (found mainly in the brain) and the CB2 receptors (found mainly in the immune system). The CB1 receptor is one of the most abundant G protein coupled receptors in the mammalian brain and it accounts for most, if not all, of the centrally mediated effects of cannabinoids. Cannabionoid receptors are evolutionarily conserved amoung various vertebrates and invertebrates which have been separate for 500 million years. [read the full article on the link below]

source = AC | Associated Content 0

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Interview: Andy Roberts

January 30th, 2010 by fernando

author of ‘Albion Dreaming – A cultural history of LSD in Britain’

thanks to Psychedelic Press UK  :

Andy Roberts is a writer and the author of ‘Albion Dreaming – A cultural history of LSD in Britain’. The first book to deal exclusively with the impact of LSD on British culture ‘Albion Dreaming’ is a thoughtfully researched space into the history of the relationship, which investigates military, scientific and social perspectives.

 Andy has been kind enough to lend PsypressUK his thoughts on psychedelic literature, the challenges of writing ‘Albion Dreaming’ and his inspirations for undertaking the project. He also looks at the web of social interactions between psychedelics and society.

As a reveller in the Seventies Free Festival movement in the UK, Andy was very much a part of the era on which he writes. Indeed, as was written in PsypressUK’s recent review of the book, it is the chapters located after the counterculture that felt most rewarding to read. We asked Andy how his interest in LSD was originally sparked:

“From first hearing about the drug as a child, I’d always wanted to take LSD. I first took it in late 1972, when I was sixteen, and the experience, as it has done with so many other people, blew my mind. I became an avid consumer of the drug and its culture. Throughout my teens, 20s, 30s and 40s I read as much as I could about acid culture, and particularly UK acid culture.”

He cites such psychedelic texts as Timothy Leary’s ‘Politics of Ecstasy’, Huxley’s ‘Doors of Perception’ and the less well-known writer (in the UK at least) Stephen Gaskin as influences. Gaskin’s books “Amazing Dope Tales and Haight Street Flashbacks [are] an engrossing, funny and true account of what it was like to be a street acid head and later acid guru in San Francisco.” As Andy embarked on a career as a writer…

“…it was always at the back of my mind that I would try and do a history of LSD in the UK, but the opportunity didn’t arise. None-the-less I started to collect information ‘just in case’ and slowly began to cultivate the idea.”

Whilst arranging a review copy of a book from Cyan Publishing, a conversation was sparked about his idea to write the history. Sample chapters and a contract soon followed and the book was published in 2008. We asked Andy what the major challenges he faced in researching and writing ‘Albion Dreaming’?

“Trying to find certain people was quite hard, at least initially, but I traced most of those I wanted to. Some wouldn’t speak to me, for reasons never stated – they just didn’t return emails, letters or calls. Others gave interviews but were quite guarded in their responses to things I knew for certain they had detailed knowledge of. I also heard on the grapevine that there was a suspicion in some quarters that I was an undercover cop!”

The paranoia and suspicion that surrounds psychedelics appears to be endemic in all facets of its research, not just the scientific but also its historical, cultural and social aspects. Aside from legal threats and such like, simple corroboration of events proved difficult. Although he managed to show chemist, Andy Munro, the ‘Operation Julie’ chapter and hear that he “was satisfied it told a ‘truth’” this was not the case for the principle characters.

“It was very difficult to trace any of the people involved in the Operation Julie events. They are all still around, but no-one seemed to want to speak. I especially wanted to speak to either of the two chemists or Christine Bott. I couldn’t find any trace of Dick Kemp (strongest rumour was that he lives in Goa, but he could be living next door for all I know!)”

 At the end of ‘Albion Dreaming’ Andy says that “if there is a conspiracy, it is an unspoken one, enacted by the British Establishment” in regard to the veils of secrecy that seemingly envelope LSD. PsypressUK asked him: In your opinion, to what extent can the science of psychedelic research be separated from the “matrix of political, legal, economic, religious and social forces“? That is to say, has science become establishment by its later refusal to engage with LSD?

“I don’t think psychedelic research can be separated from the matrix of political, legal, economic, religious and social forces. This, in part, stems from the medical establishment’s condemnation of LSD when it started to become sold on the streets. They thought it was ‘their’ drug and when it became widely used they conspired with the media to spread scare stories which quickly translated into legislation. The ‘Establishment’ will, I think, never allow science to properly research LSD etc. because it is afraid – literally – of the Pandora’s box of possibilities it opens up for individuals to see beyond the tightly controlled society we live in and in which we think we are ‘free’.”

Integrating the ’space’ of the psychedelic experience into society appears to have been the primary goal of the psychedelic movement ever since it began to form a coherence. We asked Andy if he thought the incorporation of this ’space’ differs in the US and in Britain? And, if so, how?

“Many acid heads believe the whole thing to have been a waste of time. One person from my psychedelic circle of friends in the 1970s believes ‘we were all conned’ (by the whole psychedelic movement). I don’t see that at all. It’s true, we never had the psychedelic revolution people wanted but to me the psychedelic revolution still happened – is happening – subtly. I think the integration of the psychedelic experience has penetrated deep into society in both the UK and the US in many, many ways and the attitude of individuals to their work, politics, ecology and so on.”

The complex rhizome of ‘psychedelics and society’ is played out on many interlocking plains and Andy has written an important contribution to the understanding of these relationships. PsypressUK would like to thank him for answering some questions and wish him the best of luck in all his future projects.

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About Psychedelic Medicine News

Psychedelic Medicine News is a website promoting the healthy use of psychedelics. It is concentrating all reliable, truly informative news I find in the Internet, turning it into a reference to the psychedelic community and the world. It is an attempt to bring focus into the question of validity of the real benefits of consuming this sacred substances, and how much more we can explore of our minds if we humble ourselves to the teachings of psychedelic/entheogenic/psychointegrating compounds.